Children aged ≥6 to <12 years with severe atopic dermatitis (AD) have limited treatment options. In a 16-week, randomized, placebo-controlled, phase III trial in children, dupilumab, a monoclonal antibody inhibiting …
Applications and Future Directions for Optical Coherence Tomography in Dermatology.
Optical coherence tomography (OCT) is a non-invasive optical imaging method that can generate high-resolution en-face and cross-sectional images of the skin in vivo to a maximum depth of 2mm. Whilst …
Hidradenitis Suppurativa Area and Severity Index Revised (HASI-R): psychometric property assessment.
Validated, reliable, globally-accepted outcome measurement instruments for hidradenitis suppurativa (HS) are needed. Current tools to measure the physical signs domain for HS rely on lesion counts that are time-consuming and …
Overlap between hemophagocytic lymphohistiocytosis and drug reaction and eosinophilia with systemic symptoms: a review.
Drug reaction and eosinophilia with systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DIHS), shares features with hemophagocytic lymphohistiocytosis (HLH), most notably fever, rash, and internal organ involvement. However, …
Children of the Sun: a historical look at how pediatric light therapy shaped attitudes and behaviors toward sunbathing.
Today, parents are warned to protect their children from the sun’s ultraviolet (UV) rays, the most preventable and leading cause of skin cancer. Yet, during the first half of the …
What are the best endpoints for Eczema Area and Severity Index and Scoring Atopic Dermatitis in clinical practice? A prospective observational study.
Multiple strategies have been used to evaluate the minimal important change (MIC) of the Eczema Area and Severity Index (EASI) and Scoring Atopic Dermatitis (SCORAD). The meaningfulness of these MICs …
Interventions for chronic palmoplantar pustulosis: abridged Cochrane systematic review and GRADE assessments.
Palmoplantar pustulosis (PPP) is a chronic inflammatory disease in which sterile and relapsing pustules appear on the palms and soles.To assess the effects of interventions for chronic PPP to induce …
Tildrakizumab efficacy, drug survival, and safety are comparable in patients with psoriasis with and without metabolic syndrome: Long-term results from two phase 3 randomized controlled studies (reSURFACE 1 and reSURFACE 2).
Data for the effect of metabolic syndrome (MetS) on efficacy and safety of biologic agents for psoriasis treatment are limited.To evaluate long-term tildrakizumab efficacy, drug survival, and safety in patients …
Passion fruit purple variant (Passiflora edulis Sims var. edulis) seeds extract 10% cream in acne vulgaris treatment: an open-label pilot study.
Purple variant of passion fruit (Passiflora edulis Sims var. edulis) is a tropical plant commonly used in the beverage industry. The seeds have high content of linoleic acid and piceatannol …
The global burden of chronic urticaria for the patient and society.
Chronic urticaria (CU) affects about 1% of the world population of all ages, mostly young/middle-aged females, usually lasts for several years (>1 year in 25-75% of patients), and often takes …